Acyclovir 400 mg tablets treat herpes simplex virus (HSV) infections, including genital herpes and cold sores. They also manage chickenpox and shingles (herpes zoster). Dosage depends on the specific infection and your doctor’s instructions.
Genital Herpes
For initial genital herpes outbreaks, adults typically take 400 mg five times daily for 7-10 days. Suppressive therapy, to reduce recurrence, usually involves 400 mg twice daily. Children’s dosage varies significantly based on weight and should be determined by a physician.
Cold Sores (Oral Herpes)
For cold sores, the usual adult dosage is 200 mg five times daily for 7-10 days. Early treatment is key to shortening the duration and severity of symptoms. Pediatric use requires careful dosage adjustments under medical supervision.
Chickenpox and Shingles
Treatment for chickenpox and shingles requires a different dosage regimen and duration. Adults usually take 800 mg five times daily for 7-10 days. Dosage for children depends on their weight and the doctor’s assessment.
Important Considerations
Always follow your doctor’s prescription exactly. Do not adjust the dosage without consulting your physician. Report any side effects, such as nausea, vomiting, or diarrhea, immediately. Acyclovir is not a cure, but it can effectively manage symptoms and reduce the frequency of outbreaks.


