Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. This includes prescription medications, even those you rarely use. Some medications can significantly affect how Zoloft works, or vice-versa, leading to unexpected side effects or reduced effectiveness.
Here are some examples of drug interactions that may occur:
| MAO Inhibitors (e. g., phenelzine, tranylcypromine) | Serious, potentially life-threatening reaction | Avoid combining; allow a sufficient washout period between medications. Consult your doctor for guidance. |
| NSAIDs (e. g., ibuprofen, naproxen) | Increased risk of bleeding | Monitor for bleeding; your doctor may adjust dosage or suggest alternatives. |
| Lithium | Increased risk of lithium toxicity | Close monitoring of lithium levels is necessary. |
| Warfarin | Increased risk of bleeding | Regular blood tests are needed to monitor clotting time. |
| St. John’s Wort | Reduced Zoloft effectiveness | Avoid using St. John’s Wort concurrently. |
| Other antidepressants (SSRIs, SNRIs) | Increased risk of serotonin syndrome | Careful monitoring is required, and your doctor may adjust dosages. |
This table is not exhaustive. Many other medications can interact with Zoloft. Always check with your physician or pharmacist before starting any new medication while taking Zoloft. Open communication with your healthcare provider is key to safe and effective treatment.
