Acyclovir is a prescription antiviral medication, primarily used to treat herpes simplex virus (HSV) infections, including oral herpes (cold sores) and genital herpes. It also treats chickenpox and shingles (herpes zoster).
How Acyclovir Works
Acyclovir inhibits viral DNA replication. Specifically, it’s a nucleoside analog that competes with deoxyguanosine, a building block of viral DNA. This stops the virus from multiplying, reducing the severity and duration of symptoms.
Forms and Administration
Acyclovir comes in various forms: oral tablets, capsules, topical creams, and intravenous infusions. The chosen form depends on the type and severity of the infection. Oral forms are common for treating oral or genital herpes, while intravenous administration is reserved for severe cases, like disseminated herpes. Topical creams provide localized relief for cold sores.
Dosage and Treatment Duration
Oral Herpes: Typical treatment involves several days of oral medication, with dosage varying depending on the severity of the outbreak. Your doctor will provide specific instructions. Genital Herpes: Similar to oral herpes, the treatment duration depends on the severity. Suppressive therapy, involving daily medication, may be used to reduce the frequency of outbreaks. Chickenpox and Shingles: Oral acyclovir is used to shorten the duration and severity of these infections, typically for 7-10 days. Early treatment is crucial for optimal results.
Side Effects
Common side effects include nausea, headache, and diarrhea. More serious side effects are rare but can include kidney problems and neurological issues. Report any concerning side effects to your doctor immediately.
Important Considerations
- Acyclovir doesn’t cure herpes; it manages symptoms and reduces outbreaks. It’s not effective against all viruses. Always follow your doctor’s instructions precisely regarding dosage and treatment duration. Inform your doctor about all other medications you are taking.
Alternatives and Consultations
Other antiviral medications, like valacyclovir and famciclovir, are available to treat similar infections. Your doctor can help determine the best treatment option for your specific needs. Always consult a healthcare professional for diagnosis and treatment of any viral infection.


