Consult a doctor if your cold sores are severe or unusually painful. Seek medical advice if you experience symptoms lasting longer than two weeks, or if they worsen despite using over-the-counter acyclovir.
Serious Complications Requiring Immediate Medical Attention
Immediately contact your doctor if you develop a fever higher than 100.4°F (38°C), experience swollen lymph nodes in your neck or face, have difficulty swallowing or breathing, or notice any skin changes around the affected area such as extensive redness, swelling, or pus. These could indicate a more serious infection requiring immediate treatment.
Specific Circumstances Needing Professional Assessment
People with weakened immune systems (due to HIV, cancer treatment, or other conditions) should always consult a doctor before using acyclovir, even over-the-counter. Pregnant or breastfeeding women should also seek professional advice. Children under 12 should not use over-the-counter acyclovir without a doctor’s recommendation. Finally, if you have a known allergy to acyclovir or valacyclovir, avoid over-the-counter products and contact your physician.
